Perioperative medicine & outcomes

The impact of substance use disorders on postoperative falls in major noncardiac surgery: A retrospective cohort analysis

J Clin AnesthPublished Retrospective cohort study

Main finding · Postoperative fall, matched cohortResult — go to the resultOdds ratio 1.71 95 % CI 1.06–2.75

Authors' conclusion

Patients with a substance use disorder had increased risks of postoperative falls.

Study context

Population
Adults (≥18 years) undergoing major elective noncardiac surgery, New York State Inpatient and ED Databases, 2016 to 20192.12 % with active substance use disorder
Participants
365,797 adults
Exposure
Substance use disorder vs no substance use disorder
Outcome
Postoperative fall (in-hospital fall after surgery, or ED visit for a fall within 30-days of surgical discharge)
Methodological detailspropensity-score matched
  • Propensity-score matched

Main finding

Postoperative fall, matched cohort · 30-days

Odds ratio

1.71

95 % CI 1.06–2.75

P = 0.028

Substance use disorder vs No substance use disorder
OR 1.71 (95 % CI 1.06–2.75); P = 0.028

As reported in the abstract

Observational data: associations, not effects.

Further findings

OutcomeCrude odds (95 % CI)P value
Postoperative fall, unmatched cohort (crude)Unmatched cohort2.08 (1.55–2.80)P < 0.001

Original publication

The impact of substance use disorders on postoperative falls in major noncardiac surgery: A retrospective cohort analysis. J Clin Anesth. Published 21 March 2025. doi:10.1016/j.jclinane.2025.111814

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