The Influence of Opioids on Pupil Initial Diameter and Pupillary Dilation Velocity in Intensive Care Unit (ICU) Patients
Authors' conclusion
The presence of fentanyl in blood samples from a mixed ICU population is associated with a slower pupillary dilation velocity in a concentration-dependent matter.
Study context
- Population
- Critically ill patients acutely admitted to an ICU
- Participants
- 55 participants
- Primary endpoint
- Association of each detected opioid (mass spectrometry of daily blood samples) with pupillary size and dilation velocity in the pupillary light reflex
Methodological detailslinear mixed models
- Linear mixed models
Primary result
As reported in the abstract
Pupil size, dilation velocity and opioids
Increase in dilation velocity per 1 mm increase in pupil diameter before light stimulus (mm/s), 95% CI 0.2-0.3, p < 0.001
0.2
Original publication
The Influence of Opioids on Pupil Initial Diameter and Pupillary Dilation Velocity in ICU Patients. Acta Anaesthesiol Scand. Published 23 June 2025. doi:10.
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