Perioperative medicine & outcomes
The Japanese Epidemiologic Study for Perioperative Anaphylaxis, a prospective nationwide study: clinical signs, severity, and therapeutic agents
Authors' conclusion
The clinical signs and treatments of perioperative anaphylaxis are variable, and the choice regarding epinephrine administration is based on symptom severity.
Study context
- Population
- Patients with perioperative anaphylaxis, Japananalysed
- Participants
- 43 patients
- Exposure
- No epinephrine vs i.v. epinephrine vs i.m. epinephrine
- Outcome
- Clinical signs of perioperative anaphylaxis
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
- Cardiovascular signs
- 88.4%
- Skin signs
- 81.4%
- Respiratory signs
- 60.5%
- Time from first signs to diagnosis, median (min)
- 10 (5.0-17.8)
- Epinephrine unused
- 30.2%
- Epinephrine i.v.
- 48.8%
- Epinephrine i.m.
- 20.9%
- Time from diagnosis to epinephrine, median (IQR 1.5-8.0) min
- 7
- Antihistamines and corticosteroids each used
- 69.8%
Observational data: associations, not effects.
Further findings
Mean
| Outcome | No epinephrine | i.v. epinephrine | i.m. epinephrine |
|---|---|---|---|
| Worst shock index by epinephrine use | 1.35 (SD 0.41) | 2.77 (SD 0.90) | 1.89 (SD 0.77) |
- Worst shock index by epinephrine use — Higher with i.v. epinephrine than no epinephrine and i.m. epinephrine
- P<0.001
Original publication
The Japanese Epidemiologic Study for Perioperative Anaphylaxis, a prospective nationwide study: clinical signs, severity, and therapeutic agents. Br J Anaesth. Published 24 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →