Pediatric anesthesia & critical care
The optimum time for intravenous cannulation after induction with sevoflurane in children premedicated with dexmedetomidine
Authors' conclusion
In conclusion, we suggest that the appropriate time for cannulation is 85 s (1.45 min) after the loss of eyelash reflex in children sedated with dexmedetomidine and induction with sevoflurane and nitrous oxide-oxygen mixture.
Study context
- Population
- Children aged 2–6 years, ASA I, inhalation induction (sevoflurane and nitrous oxide) for elective surgery after intranasal dexmedetomidine (2 mcg/kg) premedication
- Participants
- 40 children
- Outcome
- Optimal time for IV cannulation (no movement, cough, or laryngospasm) after loss of eyelash reflex
Methodological detailsup-down sequential method, probit analysis
- Up-down sequential method
- Probit analysis
Main finding
As reported in the abstract
Effective cannulation time after loss of eyelash reflex
Effective cannulation time in 50% of patients (95% confidence limits, 1.30-27.82 s)
14.40 s
Effective cannulation time in 95% of patients (95% confidence limits, 69.61-218.26 s)
84.64 s
Observational data: associations, not effects.
Original publication
The optimum time for intravenous cannulation after induction with sevoflurane in children premedicated with dexmedetomidine. Acta Anaesthesiol Scand. Published 21 October 2022. doi:10.
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