Neuroanesthesia & neurocritical care
The Relationship Between Manifestation of Diabetes Insipidus and Estimated Glomerular Filtration Rate in Brain Death
Main finding · DI by eGFR categoryResult — go to the resultOdds ratio 0.83 95% CI 0.76–0.90Authors' conclusion
Renal dysfunction significantly impacts DI's clinical manifestation in brain death.
Study context
- Population
- Adults declared brain dead over 12 years, ICUs of a tertiary academic hospital192 analysed
- Participants
- 234 adults
- Exposure
- Diabetes insipidus (DI) occurrence across estimated glomerular filtration rate (eGFR) categories
- eGFR ≤9.7 mL/minn = 14
- Outcome
- Central DI (polyuria, low urine specific gravity, increasing serum sodium) in relation to eGFR (simplified MDRD equation)
Methodological detailssingle-centre, prospective data collection
- Single-centre
- Prospective data collection
Main finding
DI by eGFR category
Odds ratio
0.83
95% CI 0.76–0.90
P < 0.001
Events by group
Per 10 mL/min decrease in eGFR
OR 0.83 (95% CI 0.76–0.90); P < 0.001
Per 10 mL/min decrease in eGFR, as printed
As reported in the abstract
- Proportion of DI decreased significantly with decreasing eGFR
- P < 0.001
Observational data: associations, not effects.
Further findings
DI overall
- Developed DI
- 122 (63.5%)
- Did not develop DI
- 70 (36.5%)
Original publication
The Relationship Between Manifestation of Diabetes Insipidus and Estimated Glomerular Filtration Rate in Brain Death. Crit Care Med. Published 15 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →