Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study
Authors' conclusion
This study demonstrated a declining trend in the incidence and a rise in higher FFP-to-RBC ratios in massive transfusion in association with patient outcomes for trauma from 2011 to 2020 in Japan.
Study context
- Population
- Patients emergently hospitalised for trauma receiving massive transfusion (≥20 units RBC within first 2 days), Japan, 2011–2020of 3,530,846 trauma hospitalizations
- Participants
- 5,247 participants
- Outcome
- Trends in incidence and practice patterns of massive transfusion by calendar year
Methodological detailsnationwide administrative inpatient database
- Nationwide administrative inpatient database
Main finding
As reported in the abstract
Incidence of massive transfusion overall
0.15%
Incidence of massive transfusion, 2011 to 2020 (P for trend < 0.001)
0.24% to 0.10%
Fresh frozen plasma (FFP)-to-RBC ratio, 2011 to 2020 (P for trend < 0.001)
0.77 to 1.08
Platelet-to-RBC ratio, 2011 to 2020, virtually unchanged (P for trend 0.060)
0.71 to 0.78
Observational data: associations, not effects.
Further findings
In-hospital mortality by transfusion ratio
- Lower FFP-to-RBC (< 0.75) and platelets-to-RBC ratio (< 1.00) associated with increased in-hospital mortality vs ≥ 1.00
Safety
Adverse events by transfusion ratio
- Linear increases in adverse events with increasing FFP and platelets ratios
Original publication
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