Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients with coronavirus disease-19
Authors' conclusion
Critically ill patients had PICS for a long period and followed different trajectories for each impairment component.
Study context
- Population
- Survivors of COVID-19 requiring mechanical ventilation
- Participants
- 334 survivors
- Outcome
- PICS prevalence and trajectory of its components (Barthel index, Short-Memory Questionnaire, Hospital Anxiety and Depression Scale, EQ-5D-5L) every six months
- Follow-up
- 2 years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
PICS prevalence at the four questionnaires
Post-intensive care syndrome (PICS) prevalence, 1st questionnaire
72.1%
PICS prevalence, 2nd questionnaire
78.5%
PICS prevalence, 3rd questionnaire
77.6%
PICS prevalence, 4th questionnaire
82.0%
Observational data: associations, not effects.
Further findings
Trajectories by component
- Physical function and quality of life (QOL): consistent trends of recovery or deterioration
- Cognitive function and mental health: considerable variability, fluctuating ratings in later surveys
Factors associated with impairment or recovery
- Delirium associated with worse physical and mental health and poor QOL
- Prolonged ventilation associated with poor QOL
- Living with family associated with recovery of all functions and QOL
- Extracorporeal membrane oxygenation (ECMO) associated with recovery of cognitive function and mental health
- Generalized estimating equations
Original publication
Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients with coronavirus disease-19. J Intensive Care. Published 6 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →