Unraveling the Enterococcus enigma in Intensive Care Unit (ICU) peritonitis: a multicenter cohort study
Authors' conclusion
Enterococcus spp. isolation appears common in ICU peritonitis but not independently associated with higher mortality. Early targeted antimicrobial therapy was not associated with a statistically significant improvement in outcomes.
Study context
- Population
- Consecutive adults admitted to the ICUs of four hospitals in western France with peritonitis, 2020–2022
- Participants
- 392 adults
- Exposure
- With Enterococcus infection vs Without Enterococcus infection
- With Enterococcus infectionn = 161
- Early anti-Enterococcus treatmentn = 95
- Outcome
- ICU mortality
Methodological detailsmulticentre, propensity-weighted Cox models
- Multicentre
- Propensity-weighted Cox models
Main finding
As reported in the abstract
P = 0.805
Observational data: associations, not effects.
Further findings
Factors independently associated with Enterococcus isolation (multivariable analysis)
| aOR (CI) | P value | ||
|---|---|---|---|
| Postoperative peritonitis | 2.56 (1.67–3.95) | P < 0.001 | |
| Diffuse peritonitis | 1.78 (1.10–2.89) | P = 0.020 | |
| Solid organ transplantation | 5.82 (1.18–28.76) | P = 0.031 | |
| 0.050.21520Adjusted odds ratio (log scale) |
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| 90-day survival, early anti-Enterococcus treatment (155 Enterococcus peritonitis with treatment data) · 90 daysEarly anti-Enterococcus treatment vs Without Enterococcus infection · raw population | 0.71 (0.39–1.27) | P = 0.241 | |
| 90-day survival, early anti-Enterococcus treatment (155 Enterococcus peritonitis with treatment data) · 90 daysEarly anti-Enterococcus treatment vs Without Enterococcus infection · weighted Cox regression | 0.66 (0.37–1.18) | P = 0.160 | |
| 0.20.5125Hazard ratio (log scale) |
- 90-day survival, early anti-Enterococcus treatment (155 Enterococcus peritonitis with treatment data): not associated with improved 90-day survival
Original publication
Unraveling the Enterococcus enigma in ICU peritonitis: a multicenter cohort study. Crit Care. Published 23 February 2026. doi:10.
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