Cardiac arrest & resuscitation
Vasopressin and methylprednisolone and hemodynamics after in-hospital cardiac arrest – A post hoc analysis of the Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest (VAM-IHCA) trial
Primary result · Mean cumulative noradrenaline-equivalent doseResult — go to the resultMean difference −48 ug/kg 95% CI −140 to 42.9Authors' conclusion
Treatment with vasopressin and methylprednisolone during cardiac arrest caused no difference in mean arterial blood pressure, vasopressor use, or arterial blood gases within the first 24 hours after ROSC when compared to placebo.
Study context
- Population
- Patients with in-hospital cardiac arrest who achieved return of spontaneous circulation (ROSC)all patients with ROSC
- Participants
- 186 patients
- Comparison
- Vasopressin and methylprednisolone vs placebo during cardiac arrest
- Vasopressin and methylprednisolonen = 100
- Placebon = 86reference
- Primary endpoint
- Hemodynamic effects (cumulative noradrenaline-equivalent vasopressor dose, mean arterial BP, blood gases)
- Follow-up
- First 24 hours after ROSC
Methodological detailspost hoc analysis, placebo-controlled
- Post hoc analysis
- Placebo-controlled
Primary result
Mean cumulative noradrenaline-equivalent dose
Mean difference
−48 ug/kg
95% CI −140 to 42.9
P = 0.30
By group
Vasopressin and methylprednisolone vs Placebo
mean difference −48 ug/kg (95% CI −140 to 42.9); P = 0.30
As reported in the abstract
Further findings
Glucocorticoids received during first 24 hours
Glucocorticoids received during first 24 hours
- No difference in cumulative hydrocortisone-equivalent dose
Original publication
Vasopressin and methylprednisolone and hemodynamics after in-hospital cardiac arrest – A post hoc analysis of the VAM-IHCA trial. Resuscitation. Published 3 August 2023. doi:10.
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