Pediatric anesthesia & critical care
Venous Thromboembolism Prophylaxis in High-Risk Pediatric Trauma Patients
Authors' conclusion
In this prospective study, use of cVTE based on a set of high-risk criteria was safe and did not lead to bleeding complications. Delay to initiation of cVTE was significantly associated with development of VTE.
Study context
- Population
- Pediatric trauma patients <18 years meeting defined high-risk criteria on admission, 8 free-standing pediatric hospitals, October 2019–October 2022251 received cVTE
- Participants
- 460 patients
- Exposure
- cVTE within 24 hours vs cVTE after 24 hours vs no cVTE
- cVTE within 24 hoursn = 62
- cVTE after 24 hoursn = 189
- No cVTEn = 209reference
- Outcome
- Overall VTE rate stratified by receipt and timing of cVTE
Methodological detailsmulticentre, 8 level I pediatric trauma centers
- Multicentre
- 8 level I pediatric trauma centers
Main finding
As reported in the abstract
P = 0.31
Observational data: associations, not effects.
Secondary outcomes
Time from admission to cVTE initiation and VTE
| OR (95% CI) | P value | ||
|---|---|---|---|
| Increasing time to cVTE initiation | 1.01 (1.00–1.01) | P = 0.01 | |
| 0.512Odds ratio (log scale) |
Overall VTE
- 28 VTE events among 25 patients
- 5.4%
Safety
Bleeding complications during cVTE
- No bleeding complications observed while patients received cVTE
Original publication
Venous Thromboembolism Prophylaxis in High-Risk Pediatric Trauma Patients. JAMA Surg. Published 1 October 2024. doi:10.
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