Pediatric anesthesia & critical care
Vomiting after intrathecal chemotherapy under anesthesia in pediatric patients with hematologic cancers: A cohort study
Authors' conclusion
A high incidence of vomiting was observed within 24 h after intrathecal chemotherapy under propofol deep sedation. Risk factors for this outcome were established (being female, consolidation phase of treatment, and previous kinetosis), and evidence suggested that the Eberhart score was not suitable for the studied population.
Study context
- Population
- Patients under 20 years with hematologic cancers undergoing intrathecal chemotherapy under anesthesia (propofol deep sedation)
- Participants
- 139 participants
- Outcome
- Occurrence of vomiting after the end of anesthesia
- Follow-up
- 24 h
Methodological detailsProphylactic ondansetron given before the procedure to 45.3% of patients
- Prophylactic ondansetron given before the procedure to 45.3% of patients
Main finding
As reported in the abstract
Incidence of vomiting
Incidence of vomiting within 24 h
30.9%
Vomiting prior to 6 h (of vomiting)
90.7%
Observational data: associations, not effects.
Further findings
Risk factors for vomiting
| HR (95% CI) | P value | ||
|---|---|---|---|
| Female gender | 2.47 (1.35–4.53) | p: .003 | |
| Consolidation phase of treatment | 2.16 (1.10–4.24) | p: .025 | |
| History of kinetosis | 2.49 (1.31–4.70) | p: .005 | |
| 0.20.5125Hazard ratio (log scale) |
Observed vomiting incidence by Eberhart score
Observed vomiting incidence by Eberhart score
- Incidence higher than estimated by the Eberhart score distribution
Original publication
Vomiting after intrathecal chemotherapy under anesthesia in pediatric patients with hematologic cancers: A cohort study. Paediatr Anaesth. Published 20 September 2023. doi:10.
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