ICU sedation, delirium & recovery

Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses

J Intensive CarePublished Overview of systematic reviews and meta-analyses

Authors' conclusion

Multiple risk factors associated with ICUAW were identified, warranting consideration in prevention and treatment strategies.

Study context

Population
Critically ill patients in the ICU (risk factors for ICU-acquired weakness)18 systematic reviews
Outcome
Risk factors for ICU-acquired weakness (ICUAW), modifiable and nonmodifiable
Methodological detailsoverlap analysis (corrected covered area), risk of bias assessment, Six databases searched; two pairs of reviewers selected reviews by predefined criteria; results qualitatively summarized
  • Overlap analysis (corrected covered area)
  • Risk of bias assessment
  • Six databases searched; two pairs of reviewers selected reviews by predefined criteria; results qualitatively summarized

Pooled result

As reported in the abstract

Risk factors for ICUAW

Risk factors for intensive care unit-acquired weakness (ICUAW) identified

24

Factors with meta-analyses

15

Further pooled results

Risk of bias of included reviews

Low risk of bias
12
Unclear
4
High risk of bias
2

Overlap (corrected covered area index)

Extent of overlap range
0 to 23%

Original publication

Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses. J Intensive Care. Published 5 September 2024. doi:10.1186/s40560-024-00744-0

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