Cardiac arrest & resuscitation
3-Dimensional quantification of ischemic brain injury in post-cardiac arrest patients with hypoxic-ischemic brain injury
Authors' conclusion
Atlas-based segmentation integrated with voxel-intensity ADC analysis, enabled generation of granular data on the pattern and extent of ischemic brain injury following cardiac arrest.
Study context
- Population
- Post-cardiac arrest patients with hypoxic-ischemic brain injury (HIBI)
- Participants
- 10 patients
- Outcome
- Relative ischemic lesion volume (ADC <650e-6 mm²/s) by segment, hemisphere and tissue type
Methodological detailssemi-automated analysis pipeline, atlas-based segmentation
- Semi-automated analysis pipeline
- Atlas-based segmentation
Main finding
As reported in the abstract
Relative ischemic lesion volume (% of total brain volume)
Overall
28.4
mean · SD 14.1 · % of total brain volume
White matter
33.3
SD 17.8 · %
Gray matter
24.1
SD 11.4 · %
P = 0.005
Observational data: associations, not effects.
Further findings
Overlap of susceptibility-weighted imaging (SWI) and apparent diffusion coefficient (ADC) hypointensities
- Minimal overlap, negligible confounding by intraparenchymal blood (% of all voxels)
- <1%
Original publication
3-Dimensional quantification of ischemic brain injury in post-cardiac arrest patients with hypoxic-ischemic brain injury. Resuscitation. Published 10 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →