5x-Multiplier Versus 3-Tier Model: A Pragmatic Randomized Clinical Trial for Discharge Opioid Prescriptions After Intra-Abdominal Cancer Surgery
Authors' conclusion
The 5x-multiplier algorithm resulted in fewer prescribed discharge opioids with similar 14-day consumption, refill rates, and satisfaction, compared with a 3-tier model after intra-abdominal cancer surgery.
Study context
- Population
- Adults undergoing open abdominal cancer resections by 25 surgeons (5 specialties)
- Participants
- 150 adults
- Comparison
- 5x-multiplier vs 3-tier
- 5x-multipliern = 73
- 3-tiern = 77reference
- Primary endpoint
- Coprimary: discharge opioid volume and 14-day post-discharge consumption
Methodological detailspragmatic, single-center, phase II, Nonopioid analgesic bundle used perioperatively and at discharge
- Pragmatic
- Single-center
- Phase II
- Nonopioid analgesic bundle used perioperatively and at discharge
Secondary outcomes
Discharged opioid-free
Refill rates · consistent with historical rates
P = 0.426
Patient satisfaction and symptom inventory scores
- No differences in satisfaction or symptom inventory scores
Original publication
5x-Multiplier Versus 3-Tier Model: A Pragmatic Randomized Clinical Trial for Discharge Opioid Prescriptions After Intra-Abdominal Cancer Surgery. Ann Surg. Published 22 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →