Low dose intrathecal morphine for post-cesarean analgesia with scheduled multimodal pain regimen: a prospective, randomized, open blinded end-point study
Authors' conclusion
With ketorolac and acetaminophen, intrathecal morphine 50 μg was not inferior to 100 μg evaluating time to first opioid rescue dose and opioid use over time.
Study context
- Population
- Women undergoing cesarean delivery under intrathecal bupivacaine and fentanyl, with scheduled IV ketorolac and oral acetaminophenrandomized
- Participants
- 201 women
- Comparison
- 50 μg vs 100 μg
- Primary endpoint
- Time to first analgesic request (opioid rescue dose)
- Follow-up
- First 24 hours
Methodological detailsprospective, open blinded end-point, non-inferiority
- Prospective
- Open blinded end-point
- Non-inferiority
Primary result
As reported in the abstract
Time to first rescue dose
Secondary outcomes
Total opioids used, pain at rest and with ambulation, time to first ambulation
- Not different between the two cohorts
Safety
Postoperative pruritus, nausea, vomiting
- Not different between the two cohorts
Original publication
Low dose intrathecal morphine for post-cesarean analgesia with scheduled multimodal pain regimen: a prospective, randomized, open blinded end-point study. Int J Obstet Anesth. Published 27 March 2025. doi:10.
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