Intrathecal epinephrine for cesarean delivery and intraoperative fentanyl administration: a single-center retrospective study (2018–2023).
Main finding · Intraoperative fentanyl receivedResult — go to the resultDifference 3.1% 95% CI 0.9%–5.3%Authors' conclusion
In this large retrospective study, intrathecal epinephrine (200 μg) as an adjunct to spinal anesthesia for cesarean delivery was not associated with a decrease in intravenous fentanyl administration intraoperatively; however, it was associated with a slightly longer time in the recovery unit.
Study context
- Population
- Cesarean deliveries under spinal anesthesia (hyperbaric bupivacaine 12 ± 0.5 mg, fentanyl 15 μg, morphine 150 μg), single institution, 2018–2023
- Participants
- 6,837 cesarean deliveries
- Exposure
- 200 μg epinephrine vs No epinephrine
- Outcome
- Percentage of patients receiving intraoperative fentanyl
Methodological detailssingle-centre, matched weights analysis
- Single-centre
- Matched weights analysis
Main finding
Intraoperative fentanyl received
Difference
3.1%
95% CI 0.9%–5.3%
P = 0.003
By group
200 μg epinephrine vs No epinephrine
difference 3.1% (95% CI 0.9%–5.3%); P = 0.003
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | No epinephrine | 100 μg epinephrine | 200 μg epinephrine | Difference (95% CI) | P value | |
|---|---|---|---|---|---|---|
| Opioid received in recovery unitNo epinephrine vs 200 μg epinephrine | 2.7% | — not stated in the abstract | 5.1% | - 2.4% (−4.0% to −0.7%) | P = 0.003 | |
| −6−4−202Difference (linear scale) |
— not stated in the abstract
Proportion of cases by epinephrine dose
| Outcome | Difference (minutes) | P value |
|---|---|---|
| Recovery unit time200 μg epinephrine vs No epinephrine | 6 | P = 0.003 |
Original publication
Intrathecal epinephrine for cesarean delivery and intraoperative fentanyl administration: a single-center retrospective study (2018–2023). Int J Obstet Anesth. Published 18 July 2026. doi:10.
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