Transversus abdominis plane block combined with intrathecal fentanyl versus intrathecal morphine for post-cesarean analgesia: a randomized non-inferiority clinical trial
Primary resultResult — go to the resultMean difference 0.6 95% CI −0.3 to 1.5Authors' conclusion
Bilateral TAP block with intrathecal fentanyl is not non-inferior to intrathecal morphine for post-cesarean analgesia. However, intrathecal morphine was associated with a higher incidence of pruritus.
Study context
- Population
- Mothers undergoing cesarean delivery with standard multimodal analgesia
- Participants
- 80 mothers
- Comparison
- Bilateral transversus abdominis plane (TAP) block + intrathecal fentanyl vs intrathecal morphine
- Primary endpoint
- Pain score with movement (NRS; non-inferiority margin 1)
- Follow-up
- 24 hours postoperatively
Methodological detailsnon-inferiority, sham block
- Non-inferiority
- Sham block
Primary result
As reported in the abstract
Mean difference
0.6
95% CI −0.3 to 1.5
P = 0.202
By group
TF
5.4
mean
M
4.8
mean
TF vs M
mean difference 0.6 (95% CI −0.3 to 1.5); P = 0.202
Secondary outcomes
Postoperative fentanyl consumption
P < 0.001
Safety
Pruritus
P < 0.001
Original publication
Transversus abdominis plane block combined with intrathecal fentanyl versus intrathecal morphine for post-cesarean analgesia: a randomized non-inferiority clinical trial. Reg Anesth Pain Med. Published 21 January 2025. doi:10.
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