Recovery quality of transversus abdominis plane block with liposomal bupivacaine after cesarean delivery: A randomized trial
Authors' conclusion
TAP block using either liposomal bupivacaine or a mixture of plain bupivacaine and liposomal bupivacaine provided superior quality of recovery at 24 h after cesarean delivery compared to using plain bupivacaine alone.
Study context
- Population
- Women scheduled for cesarean delivery under spinal anesthesia
- Participants
- 147 women
- Comparison
- TAP block with liposomal bupivacaine or a mixture of plain and liposomal bupivacaine vs plain bupivacaine
- Primary endpoint
- QoR-15 score
- Follow-up
- 24 h postoperatively
Primary result
As reported in the abstract
Bupivacaine
109
median · IQR 104–120
Liposomal
120
median · IQR 107–128
Mixture
122
median · IQR 112–128
Each group vs bupivacaineMedian difference (95 % CI)P value
Liposomal
7(2–13)
P = 0.011Mixture
9(4–14)
P = 0.001Secondary outcomes
QoR-15 score · 48 h postoperatively
- Higher in the liposomal and mixture groups vs bupivacaine, difference not clinically meaningful
VAS pain score and opioid consumption
- Lower pain scores at 24 h and 48 h in the liposomal and mixture groups vs bupivacaine; no significant clinical differences in pain scores or opioid consumption
Patient satisfaction with analgesia
- Higher in the liposomal and mixture groups vs bupivacaine
Original publication
Recovery quality of transversus abdominis plane block with liposomal bupivacaine after cesarean delivery: A randomized trial. J Clin Anesth. Published 11 September 2024. doi:10.
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