“A breach in the protocol for no good reason”: a surgical antimicrobial prophylaxis experience in an Ethiopian academic medical center
Authors' conclusion
The extension of antimicrobial prophylaxis did not decrease the rate of surgical site infections, reaffirming the evidence that prophylactic extension of surgical antimicrobial prophylaxis is unnecessary.
Study context
- Population
- General and vascular surgery patients with clean and clean contaminated wounds undergoing elective surgery, Ethiopian academic medical center
- Exposure
- Extended vs non-extended surgical antimicrobial prophylaxis
- Outcome
- Surgical antimicrobial prophylaxis utilization and adherence
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Surgical antimicrobial prophylaxis utilization rate
90.5%
Antibiotics unnecessarily administered (of those receiving prophylaxis)
12.6%
Prophylaxis extended beyond 24 h after surgery
40.2%
Observational data: associations, not effects.
Further findings
| Outcome | aOR | P value |
|---|---|---|
| Extended prophylaxis beyond 24 h, gastrointestinal and hepato-pancreatico-biliary surgery (subgroup)CI printed in a garbled form | 7.89 | P < 0.0001 |
Surgical site infection, overall
- Overall surgical site infection rate
- 15(6.8%)
Surgical site infection, extended vs non-extended prophylaxis
- Extended prophylaxis had no effect on surgical site infection rate
Original publication
“A breach in the protocol for no good reason”: a surgical antimicrobial prophylaxis experience in an Ethiopian academic medical center. Perioper Med (Lond). Published 13 July 2023. doi:10.
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