Mitral annular plane systolic excursion as a prognostic marker in critical illness: A systematic review and meta-analysis
Pooled result · In-hospital mortalityResult — go to the resultRelative risk 4.81 95% CI 1.28–18.04Authors' conclusion
Reduced MAPSE was associated with higher in-hospital mortality and may be a bedside marker of myocardial dysfunction. Given the limitations of the available evidence, MAPSE remains a hypothesis-generating marker requiring prospective validation.
Study context
- Population
- Critically ill adults; most patients had sepsis or septic shockpatients in ten observational studies, 414 (31.5%) had reduced mitral annular plane systolic excursion (MAPSE)
- Participants
- 1,313 adults
- Comparison
- Reduced MAPSE, dichotomized using prespecified cutoffs
- Reduced MAPSEn = 414
- Outcome
- In-hospital mortality
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Relative risk
4.81
95% CI 1.28–18.04
P = 0.02
By group
Reduced MAPSE
37.7%
Reduced MAPSE
RR 4.81 (95% CI 1.28–18.04); P = 0.02
Further pooled results
Left ventricular ejection fraction (LVEF)
| MD (95% CI) | P value | ||
|---|---|---|---|
| Reduced MAPSEI2 = 94.6% · very low certainty of evidence | −13.0% (−20.6 to −5.4) | P < 0.01 | |
| −30−20−10010Difference (linear scale) |
28-30-day mortality and exploratory outcomes
- Reduced MAPSE not associated with 28-30-day mortality or exploratory outcomes
- Very low certainty of evidence
Original publication
Mitral annular plane systolic excursion as a prognostic marker in critical illness: A systematic review and meta-analysis. J Crit Care. Published 26 October 2026. doi:10.
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