Haemodynamics, fluids & transfusion
Evaluation of the mitral velocity-time integral changes induced by a passive leg raising test as a marker of fluid responsiveness in critically ill patients
Authors' conclusion
PLR-induced changes in VTIMi reliably predict fluid responsiveness in critically ill patients.
Study context
- Population
- Septic ICU patients requiring fluid responsiveness assessment23 (46%) responders
- Participants
- 50 patients
- Comparison
- Passive leg raising (PLR)-induced change in velocity-time integral (VTIMi) vs reference PLR-induced change in velocity-time integral of the left ventricular outflow tract (VTILVOT) ≥10%
- Outcome
- Ability of PLR-induced VTIMi changes to predict fluid responsiveness (PLR-induced increase in VTILVOT ≥10%), ROC curve and gray zone analyses
Methodological detailsprospective, single-center
- Prospective
- Single-center
Performance
As reported in the abstract
Prediction of fluid responsiveness
| Test or model | AUC | Sensitivity (10% increase) | Specificity (10% increase) | Gray zone |
|---|---|---|---|---|
| VTIMi | 0.927 (95% CI: 0.849-1, p < 0.001) | 83% (95% CI: 61-95) | 96% (95% CI: 83-99) | 5% and 8%, encompassing 16% of the cohort |
VTIMi
AUC0.927 (95% CI: 0.849-1, p < 0.001)
Sensitivity (10% increase)83% (95% CI: 61-95)
Specificity (10% increase)96% (95% CI: 83-99)
Gray zone5% and 8%, encompassing 16% of the cohort
Further findings
Correlation of PLR-induced changes in VTIMi and VTILVOT
- Significant correlation
- ρ = 0.656, p < 0.001
Original publication
Evaluation of the mitral velocity-time integral changes induced by a passive leg raising test as a marker of fluid responsiveness in critically ill patients. J Clin Monit Comput. Published 8 July 2025. doi:10.
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