Haemodynamics, fluids & transfusion
Fluid responsiveness-guided preinduction volume optimization and postinduction hypotension in older adults at increased frailty risk: A randomized clinical trial
Authors' conclusion
In selected older adults at increased frailty risk, preinduction volume optimization reduced early postinduction hypotension. Differences in hypotension depth and burden were modest, and clinical benefit remains uncertain.
Study context
- Population
- Adults aged 65 years or older with Risk Analysis Index-C scores greater than 15 undergoing elective gastrointestinal surgery, Shanghai Sixth People's Hospital, Shanghai, Chinarandomized 1:1
- Participants
- One hundred adults
- Comparison
- Optimization vs Usual care
- Optimizationn = 50
- Usual caren = 50reference
- Primary endpoint
- Occurrence of any mean arterial pressure (MAP) below 65 mmHg
- Follow-up
- Postinduction minutes 1 through 15
Primary result
As reported in the abstract
Each group vs usual careRisk difference, percentage points (95% CI)P value
Optimization
−34.0(−50.1 to −14.5)
P = 0.001Each group vs usual careRelative risk (95% CI)P value
Optimization
0.53(0.36–0.78)
P = 0.001- Number needed to treat
- 3 (95% CI, 2 to 7)
- Fragility index
- 7
Further findings
Median
| Outcome | Optimization | Usual care |
|---|---|---|
| Number of scheduled observations below 65 mmHg | 0 | 2 |
Mean minimum mean arterial pressure (MAP)
- Mean minimum MAP differed by
- 4.3 mmHg
- Direction not stated
Fluid responsiveness in the optimization group
- Optimization participants fluid responsive and received colloid
- Forty-six of 50
Original publication
Fluid responsiveness-guided preinduction volume optimization and postinduction hypotension in older adults at increased frailty risk: A randomized clinical trial. J Clin Anesth. Published 9 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →