Respiratory failure & ventilation
Changes in Respiratory Variation of Velocity-Time Integral and Peak Velocity of Left Ventricular Outflow Tract after Tidal Volume Challenge Predict Fluid Responsiveness in Elderly Patients with Low Tidal Volume Ventilation: A Prospective Observational Study
Authors' conclusion
In elderly patients with low tidal volume ventilation, ΔVTITVC and ΔVpeakTVC predicted fluid responsiveness accurately and better than ΔPPVTVC.
Study context
- Population
- Critically ill elderly patients without arrhythmias under mechanical ventilation with low tidal volume45 (46.9%) responders
- Participants
- 96 patients
- Comparison
- ΔVTITVC and ΔVpeakTVC vs ΔPPVTVC after tidal volume challenge (TVC) (tidal volume 6 to 8 mL/kg predicted body weight) to predict fluid responsiveness (passive leg raising, stroke volume increase >10%)
- Outcome
- Prediction of fluid responsiveness
Methodological detailsprospective observational, tertiary teaching hospital, Mean age 75 years, 75% male
- Prospective observational
- Tertiary teaching hospital
- Mean age 75 years, 75% male
Performance
As reported in the abstract
| Test or model | AUC | In gray zone |
|---|---|---|
| ΔPPVTVC | 0.89 (95% CI 0.82-0.95, p < 0.001) | 43.8% |
| ΔVTITVC | 0.96 (95% CI 0.90-0.99, p < 0.001) | 11.5% |
| ΔVpeakTVC | 0.94 (95% CI 0.87-0.98, p < 0.001) | 19.8% |
AUC
ΔPPVTVC0.89 (95% CI 0.82-0.95, p < 0.001)
ΔVTITVC0.96 (95% CI 0.90-0.99, p < 0.001)
ΔVpeakTVC0.94 (95% CI 0.87-0.98, p < 0.001)
In gray zone
ΔPPVTVC43.8%
ΔVTITVC11.5%
ΔVpeakTVC19.8%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Changes in Respiratory Variation of Velocity-Time Integral and Peak Velocity of Left Ventricular Outflow Tract after Tidal Volume Challenge Predict Fluid Responsiveness in Elderly Patients with Low Tidal Volume Ventilation: A Prospective Observational Study. J Cardiothorac Vasc Anesth. Published 15 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →