Respiratory failure & ventilation
Which spontaneous breathing trial should be used to reproduce post-extubation respiratory effort in COVID-19-related acute respiratory distress syndrome (ARDS)? A multicenter randomized crossover study
Authors' conclusion
No SBT modality differed significantly from post-extubation respiratory effort, suggesting that none could be excluded in COVID-19-related ARDS patients.
Study context
- Population
- COVID-19-related ARDS patients mechanically ventilated at least 24 hours and ready for extubationpatients, sixty measurements of respiratory effort analyzed
- Participants
- 12 participants
- Comparison
- Respiratory effort during 3 different 15-minute spontaneous breathing trials (SBT) vs 20 minutes after extubation
Primary result
As reported in the abstract
PTPes.min · baseline and after extubation
Median PTPes.min at baseline
193.8 [170.8-227.2] cmH2O.s/min
Median PTPes.min after extubation
236.6
192.1–313.6
Further findings
| Outcome | Median paired difference (95% CI) | |
|---|---|---|
| SwingPesPost-extubation vs PSV7PEEP0 | 4.7 (0.6–9.8) | |
| SwingPes.minPost-extubation vs PSV7PEEP0 | 115.3 (4.8–297.8) | |
| −2000200400Difference (linear scale) |
- SwingPes: lower during PSV7-PEEP0 than after extubation; not significant after correction for multiple comparisons
- SwingPes.min: lower during PSV7-PEEP0 than after extubation; not significant after correction for multiple comparisons
Original publication
Which spontaneous breathing trial should be used to reproduce post-extubation respiratory effort in COVID-19-related ARDS? A multicenter randomized crossover study. Anaesth Crit Care Pain Med. Published 27 October 2026. doi:10.
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