Respiratory failure & ventilation
Spontaneous breathing trial with pressure support on positive end-expiratory pressure and extensive use of non-invasive ventilation versus T-piece in difficult-to-wean patients from mechanical ventilation: a randomized controlled trial
Authors' conclusion
An extensively-assisted weaning strategy did not lead to a shorter time to successful extubation than a standard weaning strategy.
Study context
- Population
- Difficult-to-wean intubated patients mechanically ventilated for >24 h who failed their first spontaneous breathing trial (SBT) using T-piece (TP)47 analysed per group
- Participants
- 98 participants
- Comparison
- Extensively-assisted weaning vs Standard weaning
- Extensively-assisted weaningn = 49
- Standard weaningn = 49reference
- Primary endpoint
- Time between inclusion and successful extubation (Cox model adjusted on randomization strata)
Methodological detailssingle-center, prospective, open label, superiority, two parallel groups, 1:1 balanced randomization, From May 2019 to March 2023
- Single-center
- Prospective
- Open label
- Superiority
- Two parallel groups
- 1:1 balanced randomization
- From May 2019 to March 2023
Primary result
Time until successful extubation
HR for successful extubation
0.88
95% CI 0.55–1.42
P = 0.60
By group
Extensively-assisted weaning vs Standard weaning
HR for successful extubation 0.88 (95% CI 0.55–1.42); P = 0.60
As reported in the abstract
Secondary outcomes
All secondary outcomes
- Not significantly different between groups
Original publication
Spontaneous breathing trial with pressure support on positive end-expiratory pressure and extensive use of non-invasive ventilation versus T-piece in difficult-to-wean patients from mechanical ventilation: a randomized controlled trial. Ann Intensive Care. Published 17 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →