Respiratory failure & ventilation
Spontaneous breathing trials should be adapted for each patient according to the critical illness. A new individualised approach: the GLOBAL WEAN study
Authors' conclusion
Unassisted SBTs, namely PSV0PEEP0 and T-piece trial, are the most appropriate to replicate the postextubation effort to breathe.
Study context
- Population
- Adult ICU patients on invasive mechanical ventilation for at least 24 h and ready for extubation; abdominal surgery, brain injury, chest trauma, chronic obstructive pulmonary disease (COPD) and miscellaneous500 measures of effort analysed
- Participants
- 100 patients
- Comparison
- PSV7PEEP0 vs After extubation
- Primary endpoint
- Variation of pressure-time-product per minute (PTPmin) between each SBT and after extubation
- Follow-up
- 20 min after extubation
Methodological detailsmulticentre, randomised order
- Multicentre
- Randomised order
Primary result
As reported in the abstract
PTPmin
P < 0.001
Further findings
Spontaneous breathing trials (SBT) methods replicating postextubation effort, by critical illness (subgroup)
- Brain injury: PSV0PEEP0; abdominal surgery: PSV0PEEP0 and T-piece; miscellaneous: PSV7PEEP0 and T-piece; chest trauma and COPD exacerbation: all three methods
Original publication
Spontaneous breathing trials should be adapted for each patient according to the critical illness. A new individualised approach: the GLOBAL WEAN study. Intensive Care Med. Published 25 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →