Haemodynamics, fluids & transfusion
Acute Profound Hypotension Following Intraoperative Plasma Transfusion—A Case Series
Authors' conclusion
Most transfusion reactions were characterized by profound and immediate hypotension following plasma transfusion, often presenting as isolated hypotension without biochemical or clinical evidence consistent with IgE-mediated anaphylaxis. A temporal association with the use of the Belmont Rapid Infuser RI-2 was observed. These findings should be regarded as hypothesis-generating, warranting further prospective mechanistic and safety studies.
Study context
- Population
- Patients with perioperative transfusion reactions at the Karolinska University Hospital, Sweden, June 2024 to June 2025patients with perioperative transfusion reactions included
- Participants
- Seventeen patients
- Outcome
- Hypotension
Methodological detailslocal quality registry
- Local quality registry
Main finding
As reported in the abstract
Hypotension as the sole manifestation
11 cases
Observational data: associations, not effects.
Further findings
Elevated serum tryptase among the 11 with hypotension as sole manifestation
- None of these 11 showed elevated serum tryptase levels
Transfusion details
- Patients who also received packed red blood cells
- seven
- All patients except one received plasma via a Belmont Rapid Infuser RI-2
Blood pressure drop immediately after plasma infusion
- Cases with blood pressure drop immediately after plasma infusion
- 11
Reactions in relation to Belmont Rapid Infuser withdrawal
Months
- Belmont Rapid Infuser withdrawn after
- 7
- No reactions were reported in the months following withdrawal
- 4
- Reactions recurred following subsequent device use
Original publication
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