Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage
Primary result · 30-day mortalityResult — go to the resultAdjusted odds ratio 1.24 95% CI 0.87–1.76Authors' conclusion
In injured patients with hemorrhagic shock, the use of whole blood for prehospital transfusion did not result in lower 30-day mortality than the use of blood components.
Study context
- Population
- Trauma patients receiving prehospital transfusion, transported by air medical bases44 air bases
- Participants
- 1,020 patients
- Comparison
- Prehospital whole blood vs as-indicated blood components
- Whole bloodn = 715
- Componentn = 305reference
- Primary endpoint
- Death from any cause
- Follow-up
- 30 days after randomisation
Methodological detailspragmatic, multicentre, phase 3, cluster-randomised (44 air medical bases, 2:1), 1-month blocks
- Pragmatic
- Multicentre
- Phase 3
- Cluster-randomised (44 air medical bases, 2:1)
- 1-month blocks
Primary result
30-day mortality · 30 days
Adjusted odds ratio
1.24
95% CI 0.87–1.76
P = 0.24
By group
Whole blood vs Component
aOR 1.24 (95% CI 0.87–1.76); P = 0.24
As reported in the abstract
Further findings
| Outcome | Storage 15 to 21 days | Storage 1 to 14 days | aOR (95% CI) | |
|---|---|---|---|---|
| 30-day mortality by whole-blood storage age (observational substudy) | 27.1% | 26.4% | 0.99 (0.74–1.32) | |
| 0.512Adjusted odds ratio (log scale) |
- 30-day mortality by whole-blood storage age (observational substudy): observational substudy; n = 210 and 443
Safety
- No substantial between-group differences in adverse events
Original publication
Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage. N Engl J Med. Published 18 May 2026. doi:10.
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