Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study
Authors' conclusion
Prehospital plasma transfusion for penetrating injury was associated with lower odds of death at 24-h compared to RBC alone.
Study context
- Population
- Trauma patients with traumatic hemorrhage receiving prehospital transfusion, six prehospital services in England970 recruited
- Participants
- 909 patients
- Exposure
- Prehospital combined red cell and plasma (RCP) or RBC and plasma separately (RBC + P) vs RBC alone
- RBC + Pn = 391
- RCPn = 295
- RBCn = 223reference
- Outcome
- Mortality
- Follow-up
- 24-h and 30-day
Methodological detailsprospective data collection, retrospective comparison cohort, six prehospital services, generalized estimating equations
- Prospective data collection
- Retrospective comparison cohort
- Six prehospital services
- Generalized estimating equations
Main finding
As reported in the abstract
Death · 24-h
Each group vs RBCAdjusted odds ratio (95% CI)
RCP
0.69(0.52–0.92)
RBC + P
0.60(0.32–1.13)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Death, penetrating injury (subgroup) · 24-hRBC + P vs RBC | 0.22 (0.10–0.53) | |
| Death, penetrating injury (subgroup) · 24-hRCP vs RBC | 0.39 (0.20–0.76) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Survival · 30-day
- No association between RCP or RBC + P with 30-day survival vs RBC
Original publication
Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study. Crit Care. Published 17 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →