Prehospital Whole Blood in Traumatic Hemorrhage — A Randomized Controlled Trial
Primary resultResult — go to the resultRelative risk 1.02 95% CI 0.80–1.31Authors' conclusion
Among participants with life-threatening hemorrhage, prehospital transfusion of 2 units of whole blood was not superior to standard care in reducing the risk of death or massive transfusion within 24 hours.
Study context
- Population
- Patients with major traumatic hemorrhage attended by 10 air ambulance services in England616 analysed
- Participants
- 942 patients
- Comparison
- Prehospital whole blood vs standard care with blood components
- Whole bloodn = 314
- Standard caren = 302reference
- Primary endpoint
- Composite of:
- Death from any cause
- Massive transfusion (≥10 units of blood components or products)
- Follow-up
- Within 24 hours after randomization
Methodological detailspragmatic, phase 3, multicentre, unblinded, superiority
- Pragmatic
- Phase 3
- Multicentre
- Unblinded
- Superiority
Primary result
As reported in the abstract
Relative risk
1.02
95% CI 0.80–1.31
P = 0.84
By group
Whole blood vs Standard care
RR 1.02 (95% CI 0.80–1.31); P = 0.84
Secondary outcomes
Prothrombin time above normal range
Death from any cause at all time points, massive transfusion, other secondary outcomes
- Appeared to be similar in the two groups
Safety
Events
| Outcome | Whole blood | Standard care |
|---|---|---|
| Serious adverse events | 31 | 37 |
Thrombotic events
- Appeared to be similar in the two groups
Original publication
Prehospital Whole Blood in Traumatic Hemorrhage — A Randomized Controlled Trial. N Engl J Med. Published 17 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →