What is the Incidence of Early Antibody Formation After Resuscitation of Hemorrhage? A Comparison of RH(D)+ Whole Blood and RH(D)− Red Blood Cells in 3531 Trauma Patients
Authors' conclusion
LTOWB transfusion in severely injured trauma patients was associated with a low incidence of alloantibody formation comparable to component therapy, supporting the immunohematological safety of LTOWB in trauma resuscitation.
Study context
- Population
- Adult trauma patients (15 y or older) receiving emergency release uncrossed blood products prehospital or shortly after admission, 2017 to 2023
- Participants
- 3,531 patients
- Exposure
- Rh-positive LTOWB vs Rh-negative component therapy alone
- WBn = 2,103
- COMPn = 1,428reference
- Outcome
- Incidence of alloimmunization (antibody screening on admission and at 72-hour intervals during hospitalization)
Methodological detailssingle-centre, Level I trauma centre, trauma registry data
- Single-centre
- Level I trauma centre
- Trauma registry data
Main finding
As reported in the abstract
Post-transfusion alloantibody formation
Observational data: associations, not effects.
Further findings
Antibody specificity among patients with alloantibodies
anti-D share of detected antibodies
anti-E share (most common) WB 22%
Alloantibody formation by Rh(D) status (subgroup)
- In both groups, alloantibody formation more common in Rh(D)-negative patients
Original publication
What is the Incidence of Early Antibody Formation After Resuscitation of Hemorrhage? A Comparison of RH(D)+ Whole Blood and RH(D)− Red Blood Cells in 3531 Trauma Patients. Ann Surg. Published 23 June 2026. doi:10.
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