Early hemodynamic phenotyping in sepsis using transthoracic echocardiography: A proof-of-concept study in a north African ICU
Primary result · 30-day ICU mortality by phenotypeResult — go to the resultHazard ratio 2.90 95% CI 1.24–6.79Authors' conclusion
In this first echocardiography-informed phenotyping study from an African ICU, early cardiovascular phenotypes were identifiable and associated with distinct 30-day outcomes.
Study context
- Population
- Adults with sepsis and acute circulatory failure assessed for fluid responsiveness, TTE within 24 h of ICU admission, north African ICUanalysed
- Participants
- 78 adults
- Comparison
- Echocardiography-informed cardiovascular phenotypes
- Hemodynamically optimizedn = 25reference
- Vasoplegicn = 27
- Myocardial depressedn = 26
- Primary endpoint
- ICU mortality
- Follow-up
- 30 days
Methodological detailsk-means clustering, single ICU
- K-means clustering
- Single ICU
Primary result
30-day ICU mortality by phenotype
Hazard ratio
2.90
95% CI 1.24–6.79
P = 0.014
Myocardial depressed vs Hemodynamically optimized
HR 2.90 (95% CI 1.24–6.79); P = 0.014
As reported in the abstract
- 30-day ICU mortality differed significantly across phenotypes (28% vs 59% vs 69%)
- P < 0.001
Original publication
Early hemodynamic phenotyping in sepsis using transthoracic echocardiography: A proof-of-concept study in a north African ICU. J Crit Care. Published 26 February 2026. doi:10.
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