Cardiovascular Subphenotypes in Sepsis
Authors' conclusion
Clustering analysis identified four cardiovascular subphenotypes in sepsis that reflected distinct circulatory failure mechanisms, were identifiable using simple models, and were associated with differing mortality risks and response to hemodynamic therapies.
Study context
- Population
- ICU patients with sepsis who received TTE within 7 days of sepsis onset, University Hospital ICU, Birmingham, UK, April 2016–December 2021995 derivation, 804 validation
- Exposure
- Four cardiovascular subphenotypes (classes 1-4) identified by clustering of hemodynamic and TTE parameters
- Outcome
- 90-day mortality, derivation cohort
- Follow-up
- 90 days
Methodological detailssingle-centre, unsupervised clustering, derivation and validation cohorts
- Single-centre
- Unsupervised clustering
- Derivation and validation cohorts
Main finding
As reported in the abstract
P < 0.0001
Observational data: associations, not effects.
Further findings
90-day mortality, validation cohort
P < 0.0001
Subphenotype identification by simple models
- Three-variable models had high diagnostic accuracy in identifying all subphenotypes in both cohorts
Interaction with hemodynamic management
- Association of classes with mortality varied according to vasoactive agent and fluid administration strategies
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cardiovascular Subphenotypes in Sepsis. Crit Care Med. Published 26 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →