Long-term outcomes of abnormal global longitudinal left ventricular strain during sepsis: A retrospective cohort study
Authors' conclusion
LV GLS was an independent predictor of MACE in septic patients, whereas LVEF did not show a significant association.
Study context
- Population
- Patients hospitalised with sepsis or septic shock, 2018–2022, LV GLS and Left Ventricular Ejection Fraction (LVEF) assessed within 7 days of admission595 patient-years of follow-up
- Participants
- 439 patients
- Exposure
- High LV GLS vs normal LV GLS; low vs normal LVEF
- Outcome
- MACE
- Follow-up
- Until July 2024
Methodological detailsmulticentre, open cohort
- Multicentre
- Open cohort
Main finding
As reported in the abstract
Estimate (95% CI)P value
High LV GLS vs Normal LV GLSunadjusted
HR 1.4(1.07–1.8)
P = 0.01High LV GLS vs Normal LV GLSadjusted
adjusted HR 1.38(1.01–1.9)
P = 0.04Low LVEF vs Normal LVEFunadjusted
HR 1.2(0.9–1.5)
P = 0.2Low LVEF vs Normal LVEFadjusted
adjusted HR 1.03(0.73–1.45)
P = 0.8- Patients experiencing major adverse cardiovascular events (MACE)
- 254
Observational data: associations, not effects.
Original publication
Long-term outcomes of abnormal global longitudinal left ventricular strain during sepsis: A retrospective cohort study. J Crit Care. Published 23 January 2026. doi:10.
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