Association Between Initial Left Ventricular Systolic Dysfunction and Clinical Outcome in Sepsis: A Multicenter Cohort Study
Main finding · In-hospital mortalityResult — go to the resultAdjusted odds ratio 1.81 95% CI 1.09–3.03Authors' conclusion
Severe LV systolic dysfunction (LVEF < 30%) is associated with significantly increased in-hospital mortality in sepsis patients, particularly in those with bacteremia and without preexisting CVD.
Study context
- Population
- Adults with sepsis or septic shock with echocardiography within 24 hours of sepsis recognition, 19 tertiary or university-affiliated hospitals in South Korea
- Participants
- 2,274 adults · 19 hospitals
- Exposure
- Severity of left ventricular (LV) systolic dysfunction by left ventricular ejection fraction (LVEF): mild-to-moderate (30-50%) and severe (< 30%) vs normal (> 50%)
- Normaln = 1,803reference
- Mild-to-moderaten = 356
- Severen = 115
- Outcome
- In-hospital mortality
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
Adjusted odds ratio
1.81
95% CI 1.09–3.03
By group
Severe vs Normal
aOR 1.81 (95% CI 1.09–3.03)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| In-hospital mortality, severe LV dysfunction, patients without preexisting CVD (subgroup)Severe vs Normal | 1.84 (1.08–3.13) | |
| In-hospital mortality, severe LV dysfunction, patients with bacteremia (subgroup)Severe vs Normal | 2.20 (1.5–3.22) | |
| 0.20.5125Odds ratio (log scale) |
Safety
Cardiopulmonary arrest · increased with dysfunction severity
P < 0.001
Other ICU complications
- No significant differences
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Initial Left Ventricular Systolic Dysfunction and Clinical Outcome in Sepsis: A Multicenter Cohort Study. Crit Care Med. Published 2 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →