Is Left Ventricular Systolic Dysfunction Associated With Increased Mortality Among Patients With Sepsis and Septic Shock?
Authors' conclusion
The association of LVEF to in-hospital mortality in sepsis and septic shock was U-shaped. Both severe LV systolic dysfunction (LVEF < 25%) and hyperdynamic LVEF (LVEF ≥ 70%) were associated independently with significantly higher in-hospital mortality.
Study context
- Population
- Adults with sepsis or septic shock (Sepsis-3) admitted to the medical ICU 2011–2020 with transthoracic echocardiography within 3 days of admission
- Participants
- 3,151 adults
- Exposure
- In-hospital mortality across five LV ejection fraction (LVEF) categories vs reference LVEF 55% to 70%
- LVEF < 25%n = 133
- 25% ≤ LVEF < 40%n = 305
- 40% ≤ LVEF < 55%n = 568
- 55% ≤ LVEF < 70%n = 1,792reference
- LVEF ≥ 70%n = 353
- Outcome
- Association between each LVEF classification and in-hospital mortality
Methodological detailsmultivariate logistic regression
- Multivariate logistic regression
Main finding
As reported in the abstract
In-hospital mortality
Each group vs 55% ≤ LVEF < 70%Odds ratio (95% CI)P value
LVEF < 25%
2.75(1.82–4.17)
P < 0.001LVEF ≥ 70%
1.70(1.09–1.88)
P = 0.010Observational data: associations, not effects.
Original publication
Is Left Ventricular Systolic Dysfunction Associated With Increased Mortality Among Patients With Sepsis and Septic Shock? Chest. Published 14 January 2023. doi:10.
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