ICU sedation, delirium & recovery
A Core Outcome Set for Adult General ICU Patients
Authors' conclusion
We developed and internationally validated a core outcome set with six core outcomes to be used in research, specifically clinical trials involving adult general ICU patients.
Study context
- Population
- Adult ICU survivors, family members, clinicians, and researchers; Denmark, with validation across 14 countries in Europe, Australasia, and India
- Participants
- 264 Delphi survey participants
- Outcome
- Final core outcome set for adult general ICU patients
Methodological detailsmodified Delphi consensus process, multiple methods design, literature review, survey, semi-structured interviews, three-round Delphi survey, international validation, 5 Danish research panels and 17 panels in 13 other countries, Followed the Core Outcome Measures in Effectiveness Trials Handbook
- Modified Delphi consensus process
- Multiple methods design
- Literature review
- Survey
- Semi-structured interviews
- Three-round Delphi survey
- International validation
- 5 Danish research panels and 17 panels in 13 other countries
- Followed the Core Outcome Measures in Effectiveness Trials Handbook
Recommendations
As reported in the abstract
Final core outcome set: survival, free of life support, free of delirium, out of hospital, health-related quality of life, cognitive function
6
Published outcomes identified
329
Outcomes included in the Delphi survey
50
International validation research panel members
217
Further findings
Delphi process participation
- Completed first Delphi round
- 249 (94%)
- Contributed to third and final round
- 202 (82%)
- Semi-structured interviews; no additional outcomes added
- 82
- Outcomes in initial core outcome set
- 6
Original publication
A Core Outcome Set for Adult General ICU Patients. Crit Care Med. Published 6 January 2025. doi:10.
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