A Multi-Institutional and Nationwide Analysis of the Social Determinants of Persistent Pain After Surgery
Study context
- Population
- Adults who underwent surgery after 2000 with social determinants of health (SDoH) survey data and no prior diagnosis of persistent postoperative painincluded in final analysis
- Participants
- 8,065 adults
- Exposure
- 21 SDoH survey-derived variables and persistent postoperative pain, adjusted for age, sex, race, ethnicity and surgery type
- Outcome
- Persistent postoperative pain (SNOMED-coded diagnosis ≥1 year after surgery)
- Follow-up
- At least 1 year after surgery
Methodological detailsAll of Us Research Program database, multivariable logistic regression, Bonferroni-corrected significance threshold (P < .002)
- All of Us Research Program database
- Multivariable logistic regression
- Bonferroni-corrected significance threshold (P < .002)
Main finding
As reported in the abstract
Association of SDoH with persistent postoperative pain (multivariable logistic regression) · ≥1 year after surgery
Odds ratio (95% CI)P value
Food insecuritystrongest association
1.83(1.45–2.30)
P < 0.001Greater social supportprotective
0.96(0.94–0.99)
P = 0.002Lower residential densityprotective
0.72(0.61–0.85)
P < 0.001- Persistent postoperative pain among 8065 included
- 641 (7.9%)
Observational data: associations, not effects.
Original publication
A Multi-Institutional and Nationwide Analysis of the Social Determinants of Persistent Pain After Surgery. Anesth Analg. Published 7 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →