A Novel Approach to Early Personalized Hemodynamic Resuscitation: Non‐Invasive Peripheral Photoplethysmography for Identifying Predominant Vasodilatory Shock in Sepsis
Authors' conclusion
PPG enables identification of patients likely to benefit from vasopressor therapy during the first 20 min after ED arrival.
Study context
- Population
- Adults admitted for non-trauma specialties with suspected infection and hemodynamic instability (MAP < 70 mmHg, SBP < 90 mmHg, shock index > 0.9, or lactate > 4.0 mmol/L) in the emergency department (ED), University Medical Centre Groningen
- Participants
- 325 adults
- Primary endpoint
- Discriminative performance of PPG-based models for vasopressor therapy initiation
- Follow-up
- Within 24 h
Methodological detailsprognostic modelling study, single-centre biobank, principal component analysis, K-means clustering, logistic regression
- Prognostic modelling study
- Single-centre biobank
- Principal component analysis
- K-means clustering
- Logistic regression
Primary result
As reported in the abstract
Discrimination for vasopressor initiation within 24 h
Received vasopressors
16.3%
PPG-based model AUROC (moderate discriminative power)
0.75
PPG model combined with MAP and lactate AUROC
0.83
Further findings
Principal component analysis of PPG features
- Three principal components (PC1 arterial compliance; PC2 CO and systemic vascular resistance; PC3 peripheral vasomotor tone) explaining variance
- 80.3%
Original publication
A Novel Approach to Early Personalized Hemodynamic Resuscitation: Non‐Invasive Peripheral Photoplethysmography for Identifying Predominant Vasodilatory Shock in Sepsis. Acta Anaesthesiol Scand. Published 9 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →