A novel role for ADAMTS13 in hyperfibrinolysis after trauma-induced shock☆
Authors' conclusion
During trauma-induced shock, ADAMTS13 can circulate in a truncated and hyperactivated conformation, which is associated with hyperfibrinolysis and mortality.
Study context
- Population
- Trauma patients with shock; in vitro blood from healthy volunteerstrauma patients with shock
- Participants
- 39 patients
- Comparison
- Truncated vs closed ADAMTS13 conformation
- Outcome
- Hyperfibrinolysis (rotational thromboelastometry (ROTEM) FIBTEM maximum lysis) with truncated vs closed ADAMTS13 conformation
Methodological detailsclinical cohort with in vitro experiments
- Clinical cohort with in vitro experiments
Main finding
As reported in the abstract
P = 0.002
Further findings
Mortality
P = 0.007
| Outcome | P value |
|---|---|
| Hyperfibrinolysis (ROTEM FIBTEM maximum lysis) | P = 0.002 |
Original publication
A novel role for ADAMTS13 in hyperfibrinolysis after trauma-induced shock☆. Br J Anaesth. Published 6 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →