Hemodynamics, fluids & transfusion
A pilot multicenter randomized controlled trial on individualized blood pressure targets versus standard care among critically ill patients with shock
Authors' conclusion
This pilot RCT demonstrated that an individualized MAP target strategy was feasible to implement. No adverse safety signals were evident.
Study context
- Population
- Patients aged 40 years or older receiving vasopressor support for shock, two multidisciplinary ICUs in Australia and Ireland
- Participants
- 37 patients
- Comparison
- Individualized mean arterial pressure (MAP) vs Standard MAP
- Individualized MAPn = 17
- Standard MAPn = 20reference
- Primary endpoint
- Feasibility and safety; pre-specified endpoints incl. time-weighted average MAP-deficit (percentage difference between pre-illness MAP and achieved MAP)
Methodological detailspilot, prospective, open label, parallel-group, multicentre
- Pilot
- Prospective
- Open label
- Parallel-group
- Multicentre
Primary result
As reported in the abstract
Time-weighted average MAP-deficit
P = 0.048
Further findings
Major adverse kidney events (MAKE-14) · 14 days
P = 0.67
14-day mortality
P = 0.61
90-day mortality
P = 0.67
Median
| Outcome | Individualized MAP | Standard MAP | P value |
|---|---|---|---|
| Percentage time with > 20% MAP-deficitExploratory | 8% (IQR 0–43) | 53% (IQR 14–75) | P = 0.03 |
Safety
Cardiovascular adverse events · within 28 days
- Similar for both groups
Original publication
A pilot multicenter randomized controlled trial on individualized blood pressure targets versus standard care among critically ill patients with shock. J Intensive Care. Published 27 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →