A quantitative evaluation of aerosol generation during awake tracheal intubation

AnaesthesiaPublished 29 Jan 2023Mechanistic study

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Authors' conclusion

Awake tracheal intubation and nasendoscopy can generate high concentrations of respiratory aerosol.

Study context

Population: Healthy anaesthetic trainees undergoing awake tracheal intubation and nasendoscopy with topical lidocaine, no sedation

Comparison: Aerosol during awake tracheal intubation steps and nasendoscopy vs volitional coughing
Nasendoscopyn = 38
Outcome: Peak aerosol concentration (optical particle sizer, particles.l-1)

Methodological detailsultraclean operating theatre, healthy volunteers, no sedation

As reported in the abstract

Peak aerosol concentration

Bronchoscope through vocal cords1020median · IQR [range] 645-1245 [120-48,948] · particles.l-1

Coughing1460median · IQR [range] 390-2506 [40-12,280] · particles.l-1

Lidocaine spray coughs91,700median · IQR [range] 41,907-166,774 [390-557,817] · particles.l-1

Nasendoscopy180median · IQR [range] 120-525 [0-9552] · particles.l-1

Bronchoscope through vocal cords vs Coughing: P = 0.266 · Lidocaine spray coughs vs Coughing: P < 0.001

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

A quantitative evaluation of aerosol generation during awake tracheal intubation. Anaesthesia. Published 29 January 2023. doi:10.1111/anae.15968

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