Analgesic Effect of Cocaine and Lidocaine/Xylometazoline in Healthy Volunteers Undergoing Awake Nasal Intubation: A Randomized Controlled Crossover Trial
Primary resultResult — go to the resultMean difference 3.3 mm 95% CI −4.6 to 11.1Authors' conclusion
We found no statistically significant difference in pain scores between cocaine and lidocaine/xylometazoline when administered prior to awake nasal intubation but cannot conclude that cocaine was non-inferior to lidocaine/xylometazoline.
Study context
- Population
- Healthy volunteers undergoing awake nasal intubation14 completed all three visits
- Participants
- 16 volunteers
- Comparison
- Cocaine vs lidocaine/xylometazoline before awake nasal intubation
- Primary endpoint
- Maximum pain felt during nasal ETT insertion (VAS 0-100 mm)
Methodological detailsoutcome assessor blinded, triple crossover, non-inferiority, Approved by the local research ethics committee and the national medicine agency
- Outcome assessor blinded
- Triple crossover
- Non-inferiority
- Approved by the local research ethics committee and the national medicine agency
Primary result
As reported in the abstract
Mean difference
3.3 mm
95% CI −4.6 to 11.1
P = 0.40
By group
Cocaine vs Lidocaine/xylometazoline
mean difference 3.3 mm (95% CI −4.6 to 11.1); P = 0.40
Original publication
Analgesic Effect of Cocaine and Lidocaine/Xylometazoline in Healthy Volunteers Undergoing Awake Nasal Intubation: A Randomized Controlled Crossover Trial. Acta Anaesthesiol Scand. Published 10 May 2025. doi:10.
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