Pre-oxygenation using high flow humidified nasal oxygen or face mask oxygen in pregnant people – a prospective randomised controlled crossover non-inferiority study (The HINOP2 study)
An erratum to this article was published (Int J Obstet Anesth, May 2025 ↗)
Primary result · First etO2Result — go to the resultMean difference 1.45 % 95% CI 0.19–2.72Authors' conclusion
In this cohort of pregnant people at term in a simulated environment, pre-oxygenation with HFNO was not inferior to FM pre-oxygenation.
Study context
- Population
- Healthy pregnant people at gestational age ≥37 weeks62 analysed
- Participants
- 70 people
- Comparison
- High flow nasal oxygen (HFNO) vs face mask (FM) pre-oxygenation for 3 min
- Primary endpoint
- etO2 on first expired breath after pre-oxygenation
Methodological detailscrossover, non-inferiority, simulated environment
- Crossover
- Non-inferiority
- Simulated environment
Primary result
First etO2
Mean difference
1.45 %
95% CI 0.19–2.72
P = 0.025
By group
HFNO vs FM
mean difference 1.45 % (95% CI 0.19–2.72); P = 0.025
Non-inferiority margin 5 as printed, not drawn
As reported in the abstract
Further findings
First etO2 ≥90% achieved
P = 0.002
Original publication
Pre-oxygenation using high flow humidified nasal oxygen or face mask oxygen in pregnant people – a prospective randomised controlled crossover non-inferiority study (The HINOP2 study). Int J Obstet Anesth. Published 23 July 2024. doi:10.
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