Effect of maternal oxygen supplementation for parturients undergoing elective cesarean delivery by high‑flow nasal oxygen compared with room air on fetal acid-base status: a randomized clinical trial
Authors' conclusion
High-flow nasal oxygen during elective cesarean delivery under combined spinal epidural anesthesia appears to improve fetal acid-base status and oxygenation without increasing oxidative stress.
Study context
- Population
- Patients aged 18–45 undergoing elective cesarean delivery at ≥37 weeks' gestation under combined spinal-epidural anesthesiacompleted the study protocol
- Participants
- 112 patients
- Comparison
- HFNO vs room air from epidural catheter placement until delivery
- Primary endpoint
- Umbilical artery lactate level
Methodological detailsBetween July to December 2023
- Between July to December 2023
Primary result
As reported in the abstract
Umbilical artery lactate
P = 0.003
Secondary outcomes
Umbilical artery partial pressure of oxygen
P = 0.022
Umbilical artery partial pressure of carbon dioxide
P = 0.003
| Outcome | HFNO | Room air | P value |
|---|---|---|---|
| Umbilical artery pH | 7.32 (range 7.30–7.35) | 7.31 (range 7.28–7.33) | P = 0.004 |
Apgar scores and other short-term neonatal outcomes
- No significant differences between groups
Safety
Oxidative stress markers
- No significant differences between groups
Original publication
Effect of maternal oxygen supplementation for parturients undergoing elective cesarean delivery by high‑flow nasal oxygen compared with room air on fetal acid-base status: a randomized clinical trial. Int J Obstet Anesth. Published 17 May 2026. doi:10.
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