Effect of butorphanol nasal spray administration on patient cooperativity during labor epidural placement: a single-center randomized controlled trial
Authors' conclusion
Butorphanol nasal spray emerges as an effective means to alleviate pain during epidural puncture in labor analgesia, markedly improving maternal anesthesia adherence.
Study context
- Population
- Parturients receiving epidural labor analgesia
- Participants
- 200 participants
- Comparison
- EXP vs CTRL
- Primary endpoint
- Maternal pain and maternal compliance during epidural placement
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Maternal pain intensity, cooperation, VAS pain and McGill scores · 8 min post-anesthesia
- Significantly lower pain intensity scores, improved maternal cooperation, reduced visual analogue scale (VAS) pain and McGill scores in EXP vs CTRL
- Significantly higher probabilities of pain intensity scores ≤ 6, cooperation scores ≤ 3, VAS scores ≤ 3 at 6-, 8- and 10-min post-anesthesia, and McGill scores of 0 in EXP vs CTRL
Further findings
24-h postpartum blood loss, labor duration, lactation period
- No statistically significant differences
Neonatal indicators (umbilical artery PCO2, base excess of extracellular fluid (BE-ecf), weight, Apgar score)
- No significant differences between EXP and CTRL
- Higher umbilical artery blood pH in EXP than CTRL
Original publication
Effect of butorphanol nasal spray administration on patient cooperativity during labor epidural placement: a single-center randomized controlled trial. Perioper Med (Lond). Published 23 May 2025. doi:10.
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