Endometriosis and breakthrough pain during labor epidural analgesia: a matched case-control study 2025–2026
Authors' conclusion
Endometriosis was associated with a higher incidence of breakthrough pain during labor epidural analgesia.
Study context
- Population
- Parturients receiving standardized labor epidural analgesia at a tertiary maternity center
- Participants
- 36 vs 108
- Comparison
- Endometriosis vs no endometriosis
- Endometriosisn = 36
- Controlsn = 108reference
- Outcome
- Breakthrough pain (pain score ≥ 4 despite a functioning epidural, unrelieved by patient-controlled epidural boluses, requiring anesthesiologist intervention)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Endometriosis vs ControlsAdjusted odds ratio (95% CI)P value
After adjustment
2.99(1.32–6.72)
P = 0.008- Conditional logistic regression
- OR 2.00; P = 0.023
Observational data: associations, not effects.
Original publication
Endometriosis and breakthrough pain during labor epidural analgesia: a matched case-control study 2025–2026. Int J Obstet Anesth. Published 16 May 2026. doi:10.
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