Factors associated with breakthrough pain with labor epidural analgesia: a single-center prospective study
Authors' conclusion
Rapid labor, endometriosis, and early epidural placement independently predict breakthrough pain during labor epidural analgesia.
Study context
- Population
- Parturients receiving standardized labor epidural analgesia
- Participants
- 237 participants
- Outcome
- Breakthrough pain (NRS ≥ 4 despite functioning epidural, unrelieved by PCEA, requiring anesthesiologist intervention) and its independent predictors
Methodological detailssingle-centre, tertiary maternity center
- Single-centre
- Tertiary maternity center
Main finding
As reported in the abstract
Breakthrough pain and independent predictors (multivariable logistic regression)
Estimate (95% CI)
Rapid labor
OR 29.41(9.64–89.71)
Endometriosis
OR 13.89(1.89–102.04)
Cervical dilatation at epidural placement
OR 0.74 per cm(0.63–0.88)
Per cm, as printed
- Breakthrough pain incidence
- 78 (32.9%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| High maternal satisfaction, breakthrough pain vs none75.6% vs 95.6% high satisfaction | P < 0.001 |
Original publication
Factors associated with breakthrough pain with labor epidural analgesia: a single-center prospective study. Int J Obstet Anesth. Published 14 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →