Randomized Double-Blind Study of the Effect of Injectate Temperature on Intrathecal Bupivacaine Dose Requirement in Spinal Anesthesia for Cesarean Delivery
Primary result · ED50 of intrathecal hyperbaric bupivacaineResult — go to the resultRelative potency ratio 0.84 95% CI 0.77–0.93Authors' conclusion
Warming hyperbaric bupivacaine to body temperature reduced the dose requirement for spinal anesthesia for cesarean delivery by approximately 16% (95% CI, 7%-23%).
Study context
- Population
- Healthy parturients having elective cesarean delivery under combined spinal-epidural anesthesia
- Participants
- 80 participants
- Comparison
- Intrathecal hyperbaric bupivacaine at 37 °C vs 24 °C
- Primary endpoint
- ED50 of intrathecal bupivacaine for anesthesia for cesarean delivery (modified up-down sequential analysis)
Methodological detailsdouble-blind, up-down sequential allocation
- Double-blind
- Up-down sequential allocation
Primary result
ED50 of intrathecal hyperbaric bupivacaine
Relative potency ratio
0.84
95% CI 0.77–0.93
By group
As reported in the abstract
Original publication
Randomized Double-Blind Study of the Effect of Injectate Temperature on Intrathecal Bupivacaine Dose Requirement in Spinal Anesthesia for Cesarean Delivery. Anesth Analg. Published 13 June 2024. doi:10.
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