A study of the pharmacokinetics and pharmacodynamics of oxytocin at elective caesarean delivery
Authors' conclusion
In conclusion, we observed a large variation in serum oxytocin concentrations between individuals receiving similar doses of oxytocin and were unable to establish weight-based dosing of exogenous oxytocin at caesarean delivery.
Study context
- Population
- Women at elective caesarean delivery receiving exogenous oxytocin (initiating bolus and maintenance infusion)
- Participants
- 25 women
- Outcome
- Oxytocin pharmacokinetics and pharmacodynamics in the first 40 min
- Follow-up
- First 40 min
Methodological detailsone-compartment pharmacokinetic model
- One-compartment pharmacokinetic model
Main finding
As reported in the abstract
Volume of distribution (mean [coefficient of variation])
156.1 l
18%
Clearance (mean [coefficient of variation])
83 ml.s-1
32%
Original publication
A study of the pharmacokinetics and pharmacodynamics of oxytocin at elective caesarean delivery. Anaesthesia. Published 18 August 2023. doi:10.
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